Premature Ejaculation Pills: Are They Worth Your Money?

About one in three men has premature ejaculation, which means they "shoot" after a minute or less of sexual activity. Most men and their partners have to deal with this condition, as such many men seek for solution in a bottle. So, here is everything you need to know about premature ejaculation pills.
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With so many options for pills to stop premature ejaculation, how do you know which ones work and which ones to stay away from?

What Are Premature Ejaculation Pills?

There are two main types of pills that might help you stay in bed longer:

  • Prescription medications (Rx)
  • Over-the-counter (OTC)

You can buy over-the-counter premature ejaculation pills to stop ejaculating too soon online or in sex shops and convenience stores with a glass case. But there isn’t much evidence that they can help treat ejaculation before it’s time.

If you want to take premature ejaculation pills that actually work, you should look into prescription drugs. Some doctors agree that some drugs might be able to stop men from ejaculating too early.

But this is called “off-label use” because the drugs were originally made to treat depression.

Things like:

  • Antidepressants
  • Anxiolytics (anti-anxiety) (anti-anxiety)
  • Inhibitors of phosphodiesterase (PDE)
  • Erectile dysfunction pills

When it comes to prescriptions, doctors have a lot of freedom and can pretty much give out any legal drug for any reason. So there’s no reason a doctor can’t, say, take a medicine used to treat depression and use it to treat premature ejaculation if it has the same effect.

Now, let’s take a closer look at some specific herbal and drug pills that can help men prolong the intercourse.

Herbal Pills For Premature Ejaculation

Herbal supplements are often marketed to men as a way to improve their sexual stamina and stop them from ejaculating too early.

But when you look at the herbs on the market right now, there are a few things that stand out. First of all, the ingredients in different brands are often put together in very different ways. Second, a lot of brands make crazy claims about how well they work and sometimes warn against competing products, which makes for a mess of claims that don’t make sense.

But there is one thing that many of these products have in common, and there is some evidence that it might work.

St. John’s Wort

St. John’s wort is an herb that is used in a lot of supplements. It is thought to help with a number of health problems, including:

  • Depression
  • Menopause
  • Help with healing wounds (when applied directly to the skin)

At least two studies have found that it could be a good treatment. In 2010, a study of 50 men with PE found that this herb may help with premature ejaculation by making the brain have more of the neurotransmitter serotonin.

Also, a study from 2005 found that St. John’s wort seems to affect the ability of the vas deferens (the tube that carries sperm) to contract. This is another way that this herb may prevent ejaculation before it’s time.

Now that we’ve talked about herbs, let’s talk about the prescription drugs that are sometimes used to treat premature ejaculation.

Pills for premature ejaculation that need a prescription


Dapoxetine is a selective serotonin reuptake inhibitor (SSRI), which is a type of antidepressant.

It makes it harder for the brain to get rid of serotonin, which controls mood. When serotonin stays active in the brain for longer, it can make a person feel better about their mental health. Dapoxetine works quickly, but it also leaves the body quickly, so it doesn’t block serotonin reuptake for too long.

One known side effect of Dapoxetine and other SSRIs is that they help men ejaculate before they should. Clinical tests have shown that Dapoxetine can delay ejaculation by a few minutes if it happens too soon. This, along with the fact that the drug works quickly and wears off quickly, makes it a good choice among premature ejaculation pills.

In 2005, Dapoxetine was turned down by the FDA as a treatment for ejaculating too soon. Since then, Phase III clinical trials have been going on with the drug. Since Dapoxetine has a patent and there are no generic versions on the market, it tends to be expensive.

A study from 2017 found that a lot of men who were taking Dapoxetine for PE stopped taking it. Many men stopped taking the drug because of how much it cost, how it made them feel, and how happy they were with the results.


Lexapro, which is a brand name for escitalopram, is another SSRI that can be used to treat depression in the United States.

But some doctors give it to men to stop them from ejaculating too soon. Unlike Dapoxetine, it takes about ten days for Lexapro to start working, and it can take up to three weeks for it to work fully. So, people who want to keep the sexual effects of this drug need to take it every day and not just when they feel like it. A double-blind test looked at how well Lexapro worked to stop men from ejaculating too soon.

After 12 weeks on the drug, the average IELT time for the group of men who took Lexapro was 4.9 times faster than the average IELT time for the group of men who took a placebo, which was 1.4 times faster.

Zoloft Or Sertraline

Sertraline, which is sold under the brand name Zoloft, is another SSRI. It can also be bought as a generic drug. Sertraline is one of the most commonly prescribed psychiatric drugs. It was approved by the FDA in 1991.

Again, it is sometimes given for premature ejaculation, which at least one Australian study found to be a good sign. In this study, 46 men between the ages of 22 and 63 with an average IELT of 1 minute were given increasing doses of sertraline over a few weeks.

As the dose went up, it took longer for these men to ejaculate. This suggests that sertraline could be used to treat men who ejaculate too soon. But the researchers also found that as the dose went up, more and more men said they couldn’t get an orgasm at all. This shows that it’s important to find the right dose.

What Are The Side Effects Of SSRIs:

  • Nervousness
  • Dry lips
  • Heartburn
  • Shaking
  • Nausea
  • Diarrhea
  • Constipation
  • Dizziness
  • Tiredness
  • Headache
  • Vomiting
  • Trouble falling asleep
  • Too much sweating
  • Changes in hunger or weight
  • Changes in sexual drive or ability

Some other medicines

In addition to SSRIs, the following drugs have also been looked at as possible treatments for premature ejaculation now or in the future:


Tramadol is a strong painkiller that acts like a narcotic. It is often used to treat pain, but it is sometimes given off-label to treat premature ejaculation.

Studies have shown that it does help with physical education. But it’s not clear exactly how it works to stop ejaculation. Still, it tends to stop the reuptake of the neurotransmitters norepinephrine and serotonin. This suggests that it might work in a similar way to SSRIs.

What are the side effects of Tramadol

  • Dizziness
  • Headache
  • Drowsiness
  • Illness and throwing up
  • Constipation
  • Having no strength
  • Sweating
  • Dry lips
  • Itching

If you’re thinking about going this way, you should know that there are other, much worse side effects that you can read about here.

Inhibitors of Phosphodiesterase-5 (PDE-5)

You know sildenafil (Viagra), tadalafil (Cialis), and vardenafil as drugs for erectile dysfunction (Levitra).

These medicines help get blood to the penis and keep erections going in men. There is some evidence that they could also help some men put off ejaculating.

For example, a study from 2007 found that sildenafil is a “very effective and safe” way to treat PE, and it can also make IELT higher. But not all studies have come up with the same results.

For example, a study from 2005 found that sildenafil didn’t make IELT much better. But it did make men with PE feel better about their sexual lives, in part because it made it easier for them to get another erection after ejaculating.

Modafinil (Provigil)

Most of the time, this drug is used to treat a sleep disorder called narcolepsy.

Experiments are currently being done to see how well it works as a premature ejaculation pill, and early results look good. For example, a 2016 study found that men with PE who took Modafinil had a “modest” improvement in their IELT.

Silodosin (Rapaflo)

This treatment for benign prostate tumors might work as a premature ejaculation pill. A study done in 2017 found that men who took this drug had longer IELTs.

What are Phosphodiesterase-5 Inhibitors’ side effects?

  • Headache
  • Flushing
  • Having a stuffy nose
  • Heartburn
  • Nasopharyngitis
  • Nose bleeds
  • Make your eyes more sensitive to light
  • Dyspepsia (Indigestion)

Do Pills Work For Premature Ejaculation?

Even though there is evidence for a lot of different premature ejaculation pills, it’s important to remember that none of them are magic cures, and you have to keep taking them to keep the effects going.

Also, these medicines may help some men, but not everyone. Also, keep in mind that even though some studies showed impressive increases in mean (IELT), these are averages and don’t show what happens to everyone. Plain and simple, there is no pill that can make any guy last all night in earth-shattering splendor.

Where Can You Buy Premature Ejaculation Pills?

Once your doctor gives you a prescription, you can fill it at any pharmacy, just like any other prescription.

You can find over-the-counter medicines online and in sex shops and other stores. Should you take pills from a doctor to treat ejaculating too soon? Even if you decide to go the over-the-counter (OTC) route, in the end, you and your doctor will have to decide.

Premature ejaculation can’t be completely fixed by a pill, and there’s often a trade-off between:

  • Cost
  • Side effects
  • Doctor visits
  • Time it takes to find the right one

You might try pill after pill and end up on a long, frustrating merry-go-round.

You could use that time and energy to do exercises and other things that could help you delay ejaculation.

Alternatives to premature ejaculation pills

Desensitizing sprays

Sprays that slow down ejaculation, like Promescent, are recommended by more than 2,000 urologists and can be used on demand.

The spray has lidocaine, a topical anesthetic that makes your penis less sensitive. This makes it so you feel less pain when you’re making love, which slows down ejaculation. The good thing is that you can still feel all the great sensations of sex, but they will be a little less intense. This means you can still have a satisfying orgasm.

Just spray it on ten minutes before you want to go out, and you’re good to go.


The muscles at the base of the penis get stronger when you do Kegel exercises. They are often used to treat urinary incontinence, but they can also help you delay ejaculation over time.

To carry them out:

  • For a slow count of five, tense the muscles at the base of your penis
  • Let those muscles go for five slow counts
  • Repeat three times a day until you have done ten times

Edging method

You can do this exercise while masturbating or while having sex with a partner. The goal is to help you find the “point of no return,” which is when you can no longer stop ejaculating.

As soon as you feel an orgasm coming on, stop stimulating your penis and let it rest. Then start to stimulate them again. You might sometimes go too far and ejaculate too soon. That’s okay. Over time, you’ll learn to recognize the physical feelings of your “point of no return” and adjust stimulation during sex to delay it.

Squeeze technique

Both the squeeze method and the edging method can be used together.

As soon as you feel like you can’t go back, stop stimulating and squeeze the head of the penis hard to stop the ejaculatory response. Over time, it will help you remember how to control your ejaculation by building muscle memory.

In Conclusion

When you’re having trouble, it’s natural to want a quick solution.

Talk to your doctor about whether or not you should take premature ejaculation pills. Make sure to talk about any health problems you already have and what you can expect in terms of results and side effects.

Be careful with over-the-counter premature ejaculation pills, and if you decide to try one, do a lot of research first and talk to your doctor. It’s important to know not only what you’re putting in your body but also where it came from.

In the meantime, you could try other treatments like Promescent’s delay spray. It’s a great way to treat PE on-demand, and it’s helped over 500,000 men just like you have better, longer-lasting sex.


HealthNip does not provide medical advice, diagnosis, or treatment. Any information published on this website or by this brand is not intended as a substitute for medical advice, and you should not take any action before consulting with a healthcare professional.